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Manganese induced hematological alteration in Wistar rats

Milan Chandel, Gyan Chand Jain.

Cited by (1)

Abstract
Aim: Manganese (Mn) is an essential trace metal that act as cofactor in many cellular enzymes. The present study was designed to evaluate toxic effects of manganese chloride (MnCl2.4H2O) on marker hematological parameters in rats after sub chronic exposure and after 60 days of treatment withdrawal.
Method: Adult male Wistar rats were randomly divided into five groups. In group I, the rats were treated with vehicle (0.5 ml distilled water) and served as control. The rats in group II, III and IV were exposed to MnCl2 (50, 100 and 150 mg/kg b.wt./day, p.o. respectively) for 120 days. Half of the rats of group IV were followed by 60 days post exposure recovery period and served as group V.
Results: The results of the study showed significant dose dependent decrease in red blood cell (RBC) count, hemoglobin (Hb), hematocrit (Hct) value, platelet count and significant increase in white blood cell (WBC) count after MnCl2 exposure, Whereas no significant changes were observed in mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) after treatment. Scanning electron microscopic study of blood showed a dose dependent increase in abnormal shaped RBCs in MnCl2 treated rats. Most of the effects in these parameters were recovered after 60 days of treatment withdrawal.
Conclusion: The results of the study reveals that MnCl2 exposure resulted in hematological toxicity in rats and most of the changes in these parameters recovered when Mn exposure was ceased.

Key words: Manganese, Rat, Hematological parameters


 
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This Article Cited By the following articles

Hematobiochemical Disturbances and Oxidative Stress After Subacute Manganese Chloride Exposure and Potential Protective Effects of Ebselen in Rats
Biol Trace Elem Res 2018; (): .

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Pubmed Style

Milan Chandel, Gyan Chand Jain. Manganese induced hematological alteration in Wistar rats. J Environ Occup Sci. 2016; 5(4): 77-81. doi:10.5455/jeos.20161126061501


Web Style

Milan Chandel, Gyan Chand Jain. Manganese induced hematological alteration in Wistar rats. http://www.jeosci.com/?mno=235553 [Access: December 15, 2018]. doi:10.5455/jeos.20161126061501


AMA (American Medical Association) Style

Milan Chandel, Gyan Chand Jain. Manganese induced hematological alteration in Wistar rats. J Environ Occup Sci. 2016; 5(4): 77-81. doi:10.5455/jeos.20161126061501



Vancouver/ICMJE Style

Milan Chandel, Gyan Chand Jain. Manganese induced hematological alteration in Wistar rats. J Environ Occup Sci. (2016), [cited December 15, 2018]; 5(4): 77-81. doi:10.5455/jeos.20161126061501



Harvard Style

Milan Chandel, Gyan Chand Jain (2016) Manganese induced hematological alteration in Wistar rats. J Environ Occup Sci, 5 (4), 77-81. doi:10.5455/jeos.20161126061501



Turabian Style

Milan Chandel, Gyan Chand Jain. 2016. Manganese induced hematological alteration in Wistar rats. Journal of Environmental and Occupational Science, 5 (4), 77-81. doi:10.5455/jeos.20161126061501



Chicago Style

Milan Chandel, Gyan Chand Jain. "Manganese induced hematological alteration in Wistar rats." Journal of Environmental and Occupational Science 5 (2016), 77-81. doi:10.5455/jeos.20161126061501



MLA (The Modern Language Association) Style

Milan Chandel, Gyan Chand Jain. "Manganese induced hematological alteration in Wistar rats." Journal of Environmental and Occupational Science 5.4 (2016), 77-81. Print. doi:10.5455/jeos.20161126061501



APA (American Psychological Association) Style

Milan Chandel, Gyan Chand Jain (2016) Manganese induced hematological alteration in Wistar rats. Journal of Environmental and Occupational Science, 5 (4), 77-81. doi:10.5455/jeos.20161126061501





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