E-ISSN 2146-8311
 

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Effect of N-methyl-N-nitrosurea on microRNA expression in CBA/CA mice

Krisztina Juhasz, Katalin Gombos, Katalin Gocze, Veronika Wolher, Monika Szirmai, Peter Revesz, Ingrid Magda, Andor Sebestyen, Istvan Ember.

Cited by (4)

Abstract
Aim: There is emerging evidence concerning the postexposure effect of chemical carcinogens on miRNA expression. In spite of this fact there haven’t been so many investigation so far regarding the miRNA modification induced by N-methyl-N-nitrosourea, a well known pluripotent enviromental carcinogen. The aim of the study was to evalute the acute effect of MNU on miRNA expression. Methods: We investigated the expression level of miRNAs include miR-21 oncomiR and miR-146a is involved in NFkB antiapoptotic pathway and let-7a functioning as tumor supressor targeting ras and c-myc genes. The miRNAs expression levels were determined, in the year 2011, using quantitative PCR methods in CBA/CA H2k inbred mice at 24th hour and one week after MNU treatment and the data were evaluated in 2012. Results: We found significant upregulation of miR-21 gene in liver -, spleen – and kidney tissues. The most strikingly difference was observed in the the spleen, where all miRNA genes were upregulated in both treated groups related to the controls. Let-7a was also highly expressed in the most of the investigated organs, while miR-146a showed a reduction after 24 hours as well as one week later MNU injection. Conclusions: The early alteration in expression of let-7a, miR-21 and miR-146 genes in „in vivo” animal model could indicate their involvement in the acute effect of MNU, especially in the spleen. The characterisation of miRNA profile will lead to better understanding of mechanisms underlying the development of chemically induced tumorgenesis and may even serve as possible tool for indicate carcinogen exposures.

Key words: N-methyl-N-nitrosourea, chemical carcinogen, chemically induced tumorgenesis, miRNA


 
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REFERENCES
1. Allay E, Veigl M, Gerson SL. Mice ocer-expressing human O6 alkyltransferase selectively reduce O6 methylguanine madiated carcinogenic mutations to treshold levels after N-methyl-N-nitrosurea. Oncogene. 1999; 18: 3783-3787.

http://dx.doi.org/10.1038/sj.onc.1202697

[Pubmed]   


2. Kang HM, Jang JJ, Langford C, Shin SH, Park SY, Chung YJ. DNA copy number alterations and expression of relevant genes in mouse thymic lymphomas induced by gamma-irradiation and N-methyl-N-nitrosourea. Cancer Genet Cytogenet. 2006; 166(1): 27-35.

http://dx.doi.org/10.1016/j.cancergencyto.2005.08.002

[
Pubmed]   


3. Lu J, Jiang C, Mitrenga T, Cutter G, Thompson HJ. Pathogenic characterization of 1-methyl-1-nitrosourea-induced mammary carcinomas in the rat. Carcinogenesis. 1998; 19(1): 223-227.

http://dx.doi.org/10.1093/carcin/19.1.223

[
Pubmed]   


4. Mangues R, Kahn JM, Seidman I, Pellicer A. An overexpressed N-ras proto-oncogene cooperates with N-methylnitrosourea in mouse mammary carcinogenesis. Cancer Res. 1994; 54(24): 6395-6401.

[
Pubmed]   


5. Morton D, Bailey KL, Stout CL, Weaver RJ, White KA, Lorenzen MJ, Ball DJ. N-Methyl-N-Nitrosourea (MNU): A positive control chemical for p53+/- mouse carcinogenicity studies. Toxicol Pathol. 2008; 36(7): 926-931.

http://dx.doi.org/10.1177/0192623308324959

[
Pubmed]   


6. Ando K, Saitoh A, Hino O, Takahashi R, Kimura M, Katsuki M. Chemically Induced Forestomach Papillomas in Transgenic Mice Carry Mutant Human c-Ha-ras Transgenes. Cancer Res. 1992; 52: 978-982.

[
Pubmed]   


7. Budn F, Varjas T, Nowrasteh G, Varga Z, Boncz I, Cseh J, Prantner I, Antal T, Pzsit E, Gobel G, Bauer M, Gracza T, Perjsi P, Ember I, Gyngyi Z. Early modification of c-myc, Ha-ras and p53 expressions by N-methyl-N-nitrosourea. In Vivo. 2008; 22(6): 793-797.

[
Pubmed]   


8. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004; 116(2): 281-297.

http://dx.doi.org/10.1016/S0092-8674(04)00045-5


9. Croce CM. Causes and consequences of microRNA dysregulation in cancer. Nat Reviews Genetics. 2009; 10(10): 704-714.

http://dx.doi.org/10.1038/nrg2634

[
Pubmed]    [PMC Free Fulltext]   


10. Zhang B, Pan X, Cobb GP, Anderson TA. MicroRNAs as oncogenes and tumor suppressors. Dev Biol. 2007; 302(1): 1-12.

http://dx.doi.org/10.1016/j.ydbio.2006.08.028

[
Pubmed]   


11. Lema C, Cunningham MJ. MicroRNAs and their implications in toxicological research. Toxicol Lett. 2010; 198(2): 100-105.

http://dx.doi.org/10.1016/j.toxlet.2010.06.019

[
Pubmed]   


12. Izzotti A, Calin GA, Steele VE, Cartiglia C, Longobardi M, Croce CM, De Flora S. Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs. Cancer Prev Res. 2010; 3(1): 62-72.

http://dx.doi.org/10.1158/1940-6207.CAPR-09-0202

[
Pubmed]   


13. Li Z, Braham W, Dial S, Wang Y, Guo L, Shi L, Chen T. Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosurea. BMC Genomics. 2010; 11: 609.

http://dx.doi.org/10.1186/1471-2164-11-609

[
Pubmed]    [PMC Free Fulltext]   


14. Kalscheuer S, Zhang X, Zeng Y, Upadhyaya P. Differential expression of microRNAs in early-stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis. 2008; 29(12): 2394-2399.

http://dx.doi.org/10.1093/carcin/bgn209

[
Pubmed]    [PMC Free Fulltext]   


15. Zhang B, Pan X. RDX induces aberrant expression of microRNAs in mouse brain and liver. Environ Health Perspect. 2009; 117(2): 231-240.

[
Pubmed]    [PMC Free Fulltext]   


16. Pogribny IP, Tryndyak VP, Boyko A, Rodriguez-Juarez R, Beland FA and Kovalchuk O. Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure. Mutation Res. 2007; 619(1-2): 30-37.

http://dx.doi.org/10.1016/j.mrfmmm.2006.12.006

[
Pubmed]   


17. Pogribny IP, Muskhelishvili L, Tryndyak VP, Beland FA. The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation. Toxicology and Applied Pharmacology. 2009; 235: 305-311.

http://dx.doi.org/10.1016/j.taap.2008.12.021

[
Pubmed]   


18. Melkamu T, Zhang X, Tan J, Zeng Y, Kassie F. Alteration of microRNA expression in vinyl carbamate-induced mouse lung tumors and modulation by the chemopreventive agent indole-3-carbinol. Carcinogenesis. 2010; 31(2): 252-258.

http://dx.doi.org/10.1093/carcin/bgp208

[
Pubmed]   


19. Yu T, Wang XY, Gong RG, Li A, Yang S, Cao YT, Wen YM, Wang CM, Yi XZ. The expression profile of microRNAs in a model of 7,12-dimethyl-benz[a]anthrance-induced oral carcinogenesis in Syrian hamster. J Exp Clin Cancer Res. 2009; 28(1): 64.

http://dx.doi.org/10.1186/1756-9966-28-64

[
Pubmed]    [PMC Free Fulltext]   


20. Juhsz K, Gombos K, Szirmai M, Rvsz P, Magda I, Gcze K, Ember I. DMBA Induces Deregulation of miRNA Expression of let-7, miR-21 and miR-146a in CBA/CA Mice. In Vivo. 2012; 26(1): 113-117.

[
Pubmed]   


21. Lema C, Cunningham MJ. MicroRNAs and their implications in toxicological research. Toxicol Lett. 2010; 198(2): 100-105.

http://dx.doi.org/10.1016/j.toxlet.2010.06.019

[
Pubmed]   


22. Chen T. The role of MicroRNA in Chemical Carcinogenesis. Journal of Environmental Science and Health. 2010; 28: 89-124.

[
Pubmed]   


23. Liu C, Yu J, Yu S, Lavker RM, Cai L, Liu W, Yang K, He X, Chen S. MicroRNA-21 acts as an oncomir through multiple targets in human hepatocellular carcinoma. J Hepatol. 2010; 53(1): 98-107.

http://dx.doi.org/10.1016/j.jhep.2010.02.021

[
Pubmed]   


24. Chan JA, Krichevsky AM, Kosik KS. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer. 2005; 65: 6029-6033.


25. Zhu S, Wu F, Nie D, Sheng S, Mo YY. Micro-RNA-21 targets tumor suppressor genes in invasion and metastases. Cell Res. 2008; 18: 350-9.

http://dx.doi.org/10.1038/cr.2008.24

[
Pubmed]   


26. Long GG, Goodman DG, Credille KM, Mann PC, Wilson JM, Cardy R. Hematopoietic proliferative lesions in the spleen of rasH2 transgenic mice treated with MNU. Toxicol Pathol. 2010; 38(7): 1026-36.

http://dx.doi.org/10.1177/0192623310382557

[
Pubmed]   


27. Chen D, Li Z, Chen T. Increased expression of miR-34a in mouse spleen one day after exposure to N-ethyl-N-nitrosurea. J. Appl. Toxicol. 2011; 31(5): 496-498.

http://dx.doi.org/10.1002/jat.1640

[
Pubmed]   


28. Zhao JL, Rao DS, Boldin MP, Taganov KD, O'Connell RM and Baltimore D: NF-{kappa}B dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies. Proc Natl Acad Sci U S A. 2011; 108(22): 9184-9.

http://dx.doi.org/10.1073/pnas.1105398108

[
Pubmed]    [PMC Free Fulltext]   


29. Akao Y, Nakagawa Y and Naoe T: let-7 MicroRNA functions as a potential growth suppressor in human colon cancer cells. Biol Pharm Bull. 2006; 29(5): 903-6.

http://dx.doi.org/10.1248/bpb.29.903

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How to Cite this Article
Pubmed Style

Krisztina Juhasz, Katalin Gombos, Katalin Gocze, Veronika Wolher, Monika Szirmai, Peter Revesz, Ingrid Magda, Andor Sebestyen, Istvan Ember. Effect of N-methyl-N-nitrosurea on microRNA expression in CBA/CA mice. J Environ Occup Sci. 2012; 1(2): 77-82. doi:10.5455/jeos.20120627024402


Web Style

Krisztina Juhasz, Katalin Gombos, Katalin Gocze, Veronika Wolher, Monika Szirmai, Peter Revesz, Ingrid Magda, Andor Sebestyen, Istvan Ember. Effect of N-methyl-N-nitrosurea on microRNA expression in CBA/CA mice. http://www.jeosci.com/?mno=21809 [Access: December 15, 2018]. doi:10.5455/jeos.20120627024402


AMA (American Medical Association) Style

Krisztina Juhasz, Katalin Gombos, Katalin Gocze, Veronika Wolher, Monika Szirmai, Peter Revesz, Ingrid Magda, Andor Sebestyen, Istvan Ember. Effect of N-methyl-N-nitrosurea on microRNA expression in CBA/CA mice. J Environ Occup Sci. 2012; 1(2): 77-82. doi:10.5455/jeos.20120627024402



Vancouver/ICMJE Style

Krisztina Juhasz, Katalin Gombos, Katalin Gocze, Veronika Wolher, Monika Szirmai, Peter Revesz, Ingrid Magda, Andor Sebestyen, Istvan Ember. Effect of N-methyl-N-nitrosurea on microRNA expression in CBA/CA mice. J Environ Occup Sci. (2012), [cited December 15, 2018]; 1(2): 77-82. doi:10.5455/jeos.20120627024402



Harvard Style

Krisztina Juhasz, Katalin Gombos, Katalin Gocze, Veronika Wolher, Monika Szirmai, Peter Revesz, Ingrid Magda, Andor Sebestyen, Istvan Ember (2012) Effect of N-methyl-N-nitrosurea on microRNA expression in CBA/CA mice. J Environ Occup Sci, 1 (2), 77-82. doi:10.5455/jeos.20120627024402



Turabian Style

Krisztina Juhasz, Katalin Gombos, Katalin Gocze, Veronika Wolher, Monika Szirmai, Peter Revesz, Ingrid Magda, Andor Sebestyen, Istvan Ember. 2012. Effect of N-methyl-N-nitrosurea on microRNA expression in CBA/CA mice. Journal of Environmental and Occupational Science, 1 (2), 77-82. doi:10.5455/jeos.20120627024402



Chicago Style

Krisztina Juhasz, Katalin Gombos, Katalin Gocze, Veronika Wolher, Monika Szirmai, Peter Revesz, Ingrid Magda, Andor Sebestyen, Istvan Ember. "Effect of N-methyl-N-nitrosurea on microRNA expression in CBA/CA mice." Journal of Environmental and Occupational Science 1 (2012), 77-82. doi:10.5455/jeos.20120627024402



MLA (The Modern Language Association) Style

Krisztina Juhasz, Katalin Gombos, Katalin Gocze, Veronika Wolher, Monika Szirmai, Peter Revesz, Ingrid Magda, Andor Sebestyen, Istvan Ember. "Effect of N-methyl-N-nitrosurea on microRNA expression in CBA/CA mice." Journal of Environmental and Occupational Science 1.2 (2012), 77-82. Print. doi:10.5455/jeos.20120627024402



APA (American Psychological Association) Style

Krisztina Juhasz, Katalin Gombos, Katalin Gocze, Veronika Wolher, Monika Szirmai, Peter Revesz, Ingrid Magda, Andor Sebestyen, Istvan Ember (2012) Effect of N-methyl-N-nitrosurea on microRNA expression in CBA/CA mice. Journal of Environmental and Occupational Science, 1 (2), 77-82. doi:10.5455/jeos.20120627024402





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